Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes

Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes

Apurinic/apyrimidinic (AP)-endonucleases are multifunctional enzymes that are required for cell viability. AP-endonucleases incise DNA 5′ to an AP-site; can recognize and process some damaged nucleosides; and possess 3′-phosphodiesterase, 3′-phosphatase, and endoribonuclease activities. To elucidate...

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Bibliographic Details
Main Authors: Anastasiia T. Davletgildeeva, Alexandra A. Kuznetsova, Darya S. Novopashina, Alexander A. Ishchenko, Murat Saparbaev, Olga S. Fedorova, Nikita A. Kuznetsov
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
DNA repair
apurinic/apyrimidinic endonuclease
abasic site
damaged nucleotide
endonuclease activity
3′-5′ exonuclease activity
Online Access:https://www.mdpi.com/1422-0067/23/5/2869

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https://www.mdpi.com/1422-0067/23/5/2869

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