Single cell transcriptomics reveals recent CD8T cell receptor signaling in patients with coronary artery disease

Single cell transcriptomics reveals recent CD8T cell receptor signaling in patients with coronary artery disease

Coronary artery disease (CAD) is a major cause of death worldwide. The role of CD8+ T cells in CAD is unknown. Recent studies suggest a breakdown of tolerance in atherosclerosis, resulting in active T cell receptor (TCR) engagement with self-antigens. We hypothesized that TCR engagement would leave...

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Bibliographic Details
Main Authors: Shahad Iqneibi, Ryosuke Saigusa, Amir Khan, Mohammad Oliaeimotlagh, Sujit Silas Armstrong Suthahar, Sunil Kumar, Ahmad Alimadadi, Christopher P. Durant, Yanal Ghosheh, Coleen A. McNamara, Catherine C. Hedrick, Klaus Ley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
atherosclerosis
CAD
tolerance
CD8 T cells
scRNA-seq
CITE-Seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239148/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1239148/full

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