Dual DNA Transfection Using 1,6-Hexanedithiol-Conjugated Maleimide-Functionalized PU-PEI600 For Gene Correction in a Patient iPSC-Derived Fabry Cardiomyopathy Model

Dual DNA Transfection Using 1,6-Hexanedithiol-Conjugated Maleimide-Functionalized PU-PEI600 For Gene Correction in a Patient iPSC-Derived Fabry Cardiomyopathy Model

Non-viral gene delivery holds promises for treating inherited diseases. However, the limited cloning capacity of plasmids may hinder the co-delivery of distinct genes to the transfected cells. Previously, the conjugation of maleimide-functionalized polyurethane grafted with small molecular weight po...

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Bibliographic Details
Main Authors: Chian-Shiu Chien, Yueh Chien, Yi-Ying Lin, Ping-Hsing Tsai, Shih-Jie Chou, Aliaksandr A. Yarmishyn, Elham Rastegari, Ting-Xian Wang, Hsin-Bang Leu, Yi-Ping Yang, Mong-Lien Wang, Ying-Chun Jheng, Henkie Isahwan Ahmad Mulyadi Lai, Lo-Jei Ching, Teh-Ia Huo, Jong-Yuh Cherng, Chien-Ying Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Fabry disease
cardiomyopathy
induced pluripotent stem cells
polyurethane
polyethyleneimine
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.634190/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.634190/full

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