Investigating the association between fasting insulin, erythrocytosis and HbA1c through Mendelian randomization and observational analyses

Investigating the association between fasting insulin, erythrocytosis and HbA1c through Mendelian randomization and observational analyses

BackgroundInsulin resistance (IR) with associated compensatory hyperinsulinemia (HI) are early abnormalities in the etiology of prediabetes (preT2D) and type 2 diabetes (T2D). IR and HI also associate with increased erythrocytosis. Hemoglobin A1c (HbA1c) is commonly used to diagnose and monitor preT...

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Bibliographic Details
Main Authors: Anthony Nguyen, Rana Khafagy, Habiba Hashemy, Kevin H. M. Kuo, Delnaz Roshandel, Andrew D. Paterson, Satya Dash
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
insulin resistance
hyperinsulinemia
type 2 diabetes (T2D)
hemoglobin A1c
erythrocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1146099/full

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https://www.frontiersin.org/articles/10.3389/fendo.2023.1146099/full

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