Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism

Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism

Objective: Brown adipogenesis and thermogenesis in brown and beige adipose tissue (AT) involve vascular remodeling and sympathetic neuronal guidance. Here, we investigated the molecular mechanism coordinating these processes. Methods: We used mouse models to identify the molecular target of a peptid...

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Bibliographic Details
Main Authors: Alexes C. Daquinag, Zhanguo Gao, Yongmei Yu, Mikhail G. Kolonin
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Molecular Metabolism
Subjects:
Brown adipose thermogenesis
Neurovascular
Lipolysis
Peptide
TrkA
NGF
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822001132

Internet

http://www.sciencedirect.com/science/article/pii/S2212877822001132

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