Bacterial 2′-Deoxyguanosine Riboswitch Classes as Potential Targets for Antibiotics: A Structure and Dynamics Study

Bacterial 2′-Deoxyguanosine Riboswitch Classes as Potential Targets for Antibiotics: A Structure and Dynamics Study

The spread of antibiotic-resistant bacteria represents a substantial health threat. Current antibiotics act on a few metabolic pathways, facilitating resistance. Consequently, novel regulatory inhibition mechanisms are necessary. Riboswitches represent promising targets for antibacterial drugs. Puri...

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Bibliographic Details
Main Authors: Deborah Antunes, Lucianna H. S. Santos, Ernesto Raul Caffarena, Ana Carolina Ramos Guimarães
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
2′-deoxyguanosine riboswitch
purine riboswitch
molecular dynamics simulation
network analysis
ligand binding mechanism
Online Access:https://www.mdpi.com/1422-0067/23/4/1925

Internet

https://www.mdpi.com/1422-0067/23/4/1925

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