Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-α, NF-κB, and Bax

Cyclosporine-induced kidney damage was halted by sitagliptin and hesperidin via increasing Nrf2 and suppressing TNF-α, NF-κB, and Bax

Abstract Cyclosporine A (CsA) is employed for organ transplantation and autoimmune disorders. Nephrotoxicity is a serious side effect that hampers the therapeutic use of CsA. Hesperidin and sitagliptin were investigated for their antioxidant, anti-inflammatory, and tissue-protective properties. We a...

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Bibliographic Details
Main Authors: Ahmed M. Abd-Eldayem, Sohayla Mahmoud Makram, Basim Anwar Shehata Messiha, Hanan H. Abd-Elhafeez, Mustafa Ahmed Abdel-Reheim
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Cyclosporine
Sitagliptin
Hesperidin
Nephrotoxicity
Nrf2
NF-κB
Online Access:https://doi.org/10.1038/s41598-024-57300-x

Internet

https://doi.org/10.1038/s41598-024-57300-x

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