Drug Discovery of Spinal Muscular Atrophy (SMA) from the Computational Perspective: A Comprehensive Review

Drug Discovery of Spinal Muscular Atrophy (SMA) from the Computational Perspective: A Comprehensive Review

Spinal muscular atrophy (SMA), one of the leading inherited causes of child mortality, is a rare neuromuscular disease arising from loss-of-function mutations of the survival motor neuron 1 (<i>SMN1</i>) gene, which encodes the SMN protein. When lacking the SMN protein in neurons, patien...

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Bibliographic Details
Main Authors: Li Chuin Chong, Gayatri Gandhi, Jian Ming Lee, Wendy Wai Yeng Yeo, Sy-Bing Choi
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
drug discovery
drug therapy
spinal muscular atrophy
SMA
neuromuscular disorder
computational aided drug discovery
Online Access:https://www.mdpi.com/1422-0067/22/16/8962

Internet

https://www.mdpi.com/1422-0067/22/16/8962

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