Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

Abstract Background The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB1 receptors, which can elicit psychotropic eff...

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Bibliographic Details
Main Authors: José Aguareles, Juan Paraíso-Luna, Belén Palomares, Raquel Bajo-Grañeras, Carmen Navarrete, Andrea Ruiz-Calvo, Daniel García-Rincón, Elena García-Taboada, Manuel Guzmán, Eduardo Muñoz, Ismael Galve-Roperh
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Translational Neurodegeneration
Subjects:
Cannabinoid
Huntingtin
Neurodegeneration
Neurogenesis
PPAR
Online Access:http://link.springer.com/article/10.1186/s40035-019-0148-x

Internet

http://link.springer.com/article/10.1186/s40035-019-0148-x

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