Cryopreservation of Whole Tumor Biopsies from Rectal Cancer Patients Enable Phenotypic and In Vitro Functional Evaluation of Tumor-Infiltrating T Cells

Cryopreservation of Whole Tumor Biopsies from Rectal Cancer Patients Enable Phenotypic and In Vitro Functional Evaluation of Tumor-Infiltrating T Cells

TILs comprise functionally distinct conventional and unconventional T cell subsets and their role in responses to CRC treatments is poorly understood. We explored recovery of viable TILs from cryopreserved tumor biopsies of (chemo)-radiated patients with rectal cancer to establish a platform for ret...

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Bibliographic Details
Main Authors: Frank Liang, Azar Rezapour, Peter Falk, Eva Angenete, Ulf Yrlid
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
rectal cancer
tumor-infiltrating lymphocytes
γδ T cells
MAIT cells
IFN-γ responses
flow cytometry
Online Access:https://www.mdpi.com/2072-6694/13/10/2428

Internet

https://www.mdpi.com/2072-6694/13/10/2428

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