Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition

Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition

Type 1 diabetes results from an autoimmune attack directed at pancreatic beta cells predominantly mediated by T cells. Transplantation of stem cell derived beta-like cells (sBC) have been shown to rescue diabetes in preclinical animal models. However, how sBC will respond to an inflammatory environm...

Full description

Bibliographic Details
Main Authors: Roberto Castro-Gutierrez, Aimon Alkanani, Clayton E. Mathews, Aaron Michels, Holger A. Russ
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Endocrinology
Subjects:
autoimmune type 1 diabetes
stem cell derived pancreatic insulin producing beta-like cells
beta- immune cell interface
PD-L1 and HLA class I
beta cell replacement therapy
genome engineering
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.707881/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.707881/full

Similar Items