Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection

In addition to their role as effector cells in virus control, natural killer (NK) cells have an immunoregulatory function in shaping the antiviral T-cell response. This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine secretion upon...

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Bibliographic Details
Main Authors: Maja eArapovic, Ilija eBrizic, Branka ePopovic, Slaven eJurkovic, Stefan eJordan, Astrid eKrmpotic, Jurica eArapovic, Stipan eJonjic
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Immunology
Subjects:
Perforin
NK cells
proliferation
Bone marrow chimera
Mouse cytomegalovirus
Ly49H
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00133/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00133/full

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