Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development

Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development

Abstract Background Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac are effective for colorectal cancer prevention in humans and some animal models, but concerns over gastro-intestinal (GI) ulceration and bleeding limit their potential for chemopreventive use in broader p...

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Bibliographic Details
Main Authors: Jennifer S. Davis, Preeti Kanikarla-Marie, Mihai Gagea, Patrick L. Yu, Dexing Fang, Manu Sebastian, Peiying Yang, Ernest Hawk, Roderick Dashwood, Lenard M. Lichtenberger, David Menter, Scott Kopetz
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Chemoprevention
Gastrointestinal safety
Sulindac
Polyps
Online Access:http://link.springer.com/article/10.1186/s12885-020-07311-4

Internet

http://link.springer.com/article/10.1186/s12885-020-07311-4

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