Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release.

Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release.

Cyclic GMP-AMP synthase (cGAS) plays a key role in the innate immune responses to both DNA and RNA virus infection. Here, we found that enterovirus 71 (EV-A71), Seneca Valley virus (SVV), and foot-and-mouth disease virus (FMDV) infection triggered mitochondria damage and mitochondrial DNA (mtDNA) re...

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Bibliographic Details
Main Authors: Huisheng Liu, Zixiang Zhu, Qiao Xue, Fan Yang, Zongqiang Li, Zhaoning Xue, Weijun Cao, Jijun He, Jianhong Guo, Xiangtao Liu, Andrew E Shaw, Donald P King, Haixue Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011132

Internet

https://doi.org/10.1371/journal.ppat.1011132

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