Mycobacterium tuberculosis co-operonic PE32/PPE65 proteins alter host immune responses by hampering Th1 response

Mycobacterium tuberculosis co-operonic PE32/PPE65 proteins alter host immune responses by hampering Th1 response

PE/PPE genes, present in cluster with ESAT-6 like genes, are suspected to have a role in antigenic variation and virulence of Mycobacterium tuberculosis. Their roles in immune evasion and immune modulation of host are also well documented. We present evidence that PE32/PPE65 present within the RD8 r...

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Bibliographic Details
Main Authors: Mohd eKhubaib, Javaid Ahmad Sheikh, Saurabh ePandey, Battu eSrikanth, Manish eBhuwan, Nooruddin eKhan, Seyed Ehtesham Hasnain, Nasreen Zafar Ehtesham
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Microbiology
Subjects:
CD4+ T cells
CD8+ T cells
M.tuberculosis
PE32/PPE65
IgG subtyping
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00719/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00719/full

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