Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
Using a transgenic mouse model that recapitulates abacavir hypersensitivity syndrome, an idiosyncratic adverse drug reaction, Susukida et al show that individual differences in the immune tolerance system affect the susceptibility to idiosyncratic drug toxicity.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02657-2 |