Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging

Detection of increased pyruvate dehydrogenase flux in the human heart during adenosine stress test using hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging

Abstract Background Hyperpolarized (HP) [1-13C]pyruvate cardiovascular magnetic resonance (CMR) imaging can visualize the uptake and intracellular conversion of [1-13C]pyruvate to either [1-13C]lactate or 13C-bicarbonate depending on the prevailing metabolic state. The aim of the present study was t...

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Main Authors: Steen Hylgaard Joergensen, Esben Soevsoe S. Hansen, Nikolaj Bøgh, Lotte Bonde Bertelsen, Peter Bisgaard Staehr, Rolf F. Schulte, Craig Malloy, Henrik Wiggers, Christoffer Laustsen
格式: 文件
语言:English
出版: Elsevier 2022-06-01
丛编:Journal of Cardiovascular Magnetic Resonance
主题:
Cardiac metabolism
Stress test
Metabolic imaging
Perfusion
在线阅读:https://doi.org/10.1186/s12968-022-00860-6

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https://doi.org/10.1186/s12968-022-00860-6

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