NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties

NDR1 increases NOTCH1 signaling activity by impairing Fbw7 mediated NICD degradation to enhance breast cancer stem cell properties

Abstract Background The existence of breast cancer stem cells (BCSCs) causes tumor relapses, metastasis and resistance to conventional therapy in breast cancer. NDR1 kinase, a component of the Hippo pathway, plays important roles in multiple biological processes. However, its role in cancer stem cel...

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Bibliographic Details
Main Authors: Ling-Ling Wang, Xiao-Yun Wan, Chun-Qi Liu, Fei-Meng Zheng
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Molecular Medicine
Subjects:
NDR1
NOTCH signaling
Cancer stem cell
Fbw7
Breast cancer
Online Access:https://doi.org/10.1186/s10020-022-00480-x

Internet

https://doi.org/10.1186/s10020-022-00480-x

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