Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical specimens

Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical specimens

Abstract Background Routine clinical management of breast cancer (BC) currently depends on surrogate subtypes according to estrogen- (ER) and progesterone (PR) receptor, Ki-67, and HER2-status. However, there has been growing demand for reduced immunohistochemistry (IHC) turnaround times. The Xpert®...

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Bibliographic Details
Main Authors: Slavica Janeva, Toshima Z. Parris, Salmir Nasic, Shahin De Lara, Karolina Larsson, Riccardo A. Audisio, Roger Olofsson Bagge, Anikó Kovács
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Cancer
Subjects:
Surrogate subtyping
Breast cancer biomarker assays
Immunohistochemistry
PCR
mRNA
STRAT4
Online Access:https://doi.org/10.1186/s12885-021-08171-2

Internet

https://doi.org/10.1186/s12885-021-08171-2

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