Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet
Abstract This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solut...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2020-08-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/pdf/aabc/v92n2/0001-3765-aabc-92-02-e20191230.pdf |
| _version_ | 1819006344584232960 |
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| author | TERESA P. BEDÊ VANESSA A. JESUZ VANESSA R. SOUZA MONIQUE B. ELIAS FELIPE L. OLIVEIRA JULIANA F. DIAS ANDERSON J. TEODORO VILMA B. AZEREDO |
| author_facet | TERESA P. BEDÊ VANESSA A. JESUZ VANESSA R. SOUZA MONIQUE B. ELIAS FELIPE L. OLIVEIRA JULIANA F. DIAS ANDERSON J. TEODORO VILMA B. AZEREDO |
| author_sort | TERESA P. BEDÊ |
| collection | DOAJ |
| description | Abstract This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver. |
| first_indexed | 2024-12-21T00:07:12Z |
| format | Article |
| id | doaj.art-070f03eb02024e23935d23425324d3c1 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-21T00:07:12Z |
| publishDate | 2020-08-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-070f03eb02024e23935d23425324d3c12022-12-21T19:22:26ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902020-08-0192210.1590/0001-3765202020191230Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat dietTERESA P. BEDÊhttps://orcid.org/0000-0001-6605-1749VANESSA A. JESUZhttps://orcid.org/0000-0001-6934-7078VANESSA R. SOUZAhttps://orcid.org/0000-0002-9108-0709MONIQUE B. ELIAShttps://orcid.org/0000-0001-5062-1401FELIPE L. OLIVEIRAhttps://orcid.org/0000-0001-6193-1616JULIANA F. DIAShttps://orcid.org/0000-0001-8559-0422ANDERSON J. TEODOROhttps://orcid.org/0000-0002-0949-9528VILMA B. AZEREDOhttps://orcid.org/0000-0002-9934-7017Abstract This work evaluated the effect of grape juice, red wine and resveratrol in liver parameters of rats submitted to high-fat diet. Experimental model was conducted with groups of adult females Rattus norvegicus: control (CG); high-fat (HG); grape juice (JG); red wine (RW) and resveratrol solution (RG). The high-fat diet significantly altered hepatocytes and Kupffer cells in all treated groups. HG group presented severe steatosis followed hepatocyte ballooning and tissue damages. JG group minimized hepatic histological lesion caused by high-fat diet and WG group also induced steatosis and inflammation in hepatocytes, similar to HG. Still, resveratrol protected the tissue against fatty liver disease by reducing fat infiltration and inflammation, indicating possible therapeutic effects on the liver. Cell cycle analysis showed that HG promoted damage to the tissue, reducing the viable cell content and increasing apoptosis, even when associated with wine consumption or isolated resveratrol. However, JG protected the liver against cell damage generated by the diet. Consumption of grape juice, even associated with a high-fat diet, represents a promising protection of the liver against cellular damage, but red wine further affects the tissue, and resveratrol alone was able to reduce damage but did not minimize cellular damage to the liver.http://www.scielo.br/pdf/aabc/v92n2/0001-3765-aabc-92-02-e20191230.pdfGrape juicehigh-fat dietliverresveratrolwine |
| spellingShingle | TERESA P. BEDÊ VANESSA A. JESUZ VANESSA R. SOUZA MONIQUE B. ELIAS FELIPE L. OLIVEIRA JULIANA F. DIAS ANDERSON J. TEODORO VILMA B. AZEREDO Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet Anais da Academia Brasileira de Ciências Grape juice high-fat diet liver resveratrol wine |
| title | Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet |
| title_full | Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet |
| title_fullStr | Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet |
| title_full_unstemmed | Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet |
| title_short | Effects of grape juice, red wine and resveratrol on liver parameters of rat submitted high-fat diet |
| title_sort | effects of grape juice red wine and resveratrol on liver parameters of rat submitted high fat diet |
| topic | Grape juice high-fat diet liver resveratrol wine |
| url | http://www.scielo.br/pdf/aabc/v92n2/0001-3765-aabc-92-02-e20191230.pdf |
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