A tetracationic porphyrin with dual anti-prion activity

A tetracationic porphyrin with dual anti-prion activity

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Summary: Prions are deadly infectious agents made of PrPSc, a misfolded variant of the cellular prion protein (PrPC) which self-propagates by inducing misfolding of native PrPC. PrPSc can adopt different pathogenic conformations (prion strains), which can be resistant to potential drugs, or acquire...

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Main Authors: Antonio Masone, Chiara Zucchelli, Enrico Caruso, Giada Lavigna, Hasier Eraña, Gabriele Giachin, Laura Tapella, Liliana Comerio, Elena Restelli, Ilaria Raimondi, Saioa R. Elezgarai, Federica De Leo, Giacomo Quilici, Lorenzo Taiarol, Marvin Oldrati, Nuria L. Lorenzo, Sandra García-Martínez, Alfredo Cagnotto, Jacopo Lucchetti, Marco Gobbi, Ilaria Vanni, Romolo Nonno, Michele A. Di Bari, Mark D. Tully, Valentina Cecatiello, Giuseppe Ciossani, Sebastiano Pasqualato, Eelco Van Anken, Mario Salmona, Joaquín Castilla, Jesús R. Requena, Stefano Banfi, Giovanna Musco, Roberto Chiesa
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:iScience
Subjects:
Pharmacology
Molecular neuroscience
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015572

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http://www.sciencedirect.com/science/article/pii/S2589004223015572

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