Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Intrathecal Injection of the Secretome from ALS Motor Neurons Regulated for miR-124 Expression Prevents Disease Outcomes in SOD1-G93A Mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy. We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) and established its implication in mSOD1 MN degeneration and glial cel...

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Bibliographic Details
Main Authors: Marta Barbosa, Marta Santos, Nídia de Sousa, Sara Duarte-Silva, Ana Rita Vaz, António J. Salgado, Dora Brites
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomedicines
Subjects:
ALS mouse model
anti-microRNA-124
intraspinal delivery route
neuroprotection
prevention of glial dysfunction
preservation of motor performance
Online Access:https://www.mdpi.com/2227-9059/10/9/2120

Internet

https://www.mdpi.com/2227-9059/10/9/2120

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