Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA

Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA

Endogenous reprogramming of pancreas-derived non-beta cells into insulin-producing cells is a promising approach to treat type 1 diabetes (T1D). One strategy that has yet to be explored is the specific delivery of insulin-producing essential genes, Pdx1 and MafA, to pancreatic alpha cells to reprogr...

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Bibliographic Details
Main Authors: Ping Guo, Ting Zhang, Aiping Lu, Chiyo Shiota, Matthieu Huard, Kaitlyn E. Whitney, Johnny Huard
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
type 1 diabetes (T1D)
glucagon (GCG) promoter
pancreatic and duodenal homeobox 1 (Pdx1)
v-maf musculoaponeurotic fibrosarcoma oncogene family
protein a (MafA)
adeno-associated virus (AAV) vector
Online Access:http://www.sciencedirect.com/science/article/pii/S232905012300013X

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http://www.sciencedirect.com/science/article/pii/S232905012300013X

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