Global analysis of suppressor mutations that rescue human genetic defects
Abstract Background Genetic suppression occurs when the deleterious effects of a primary “query” mutation, such as a disease-causing mutation, are rescued by a suppressor mutation elsewhere in the genome. Methods To capture existing knowledge on suppression relationships between human genes, we exam...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
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| Series: | Genome Medicine |
| Online Access: | https://doi.org/10.1186/s13073-023-01232-0 |