Challenging interpretation of germline TP53 variants based on the experience of a national comprehensive cancer centre
Abstract TP53 variant interpretation is still challenging, especially in patients with attenuated Li–Fraumeni syndrome (LFS). We investigated the prevalence of pathogenic/likely pathogenic (P/LP) variants and LFS disease in the Hungarian population of cancer patients. By testing 893 patients with mu...
| Main Authors: | , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
Nature Portfolio
2023-08-01
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| 丛编: | Scientific Reports |
| 在线阅读: | https://doi.org/10.1038/s41598-023-41481-y |