Targeting the Cation-Chloride Co-Transporter NKCC1 to Re-Establish GABAergic Inhibition and an Appropriate Excitatory/Inhibitory Balance in Selective Neuronal Circuits: A Novel Approach for the Treatment of Alzheimer’s Disease

Targeting the Cation-Chloride Co-Transporter NKCC1 to Re-Establish GABAergic Inhibition and an Appropriate Excitatory/Inhibitory Balance in Selective Neuronal Circuits: A Novel Approach for the Treatment of Alzheimer’s Disease

GABA, the main inhibitory neurotransmitter in the adult brain, depolarizes and excites immature neurons because of an initially higher intracellular chloride concentration [Cl<sup>−</sup>]i due to the delayed expression of the chloride exporter KCC2 at birth. Depolarization-induced calci...

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Bibliographic Details
Main Authors: Simona Capsoni, Ivan Arisi, Francesca Malerba, Mara D’Onofrio, Antonino Cattaneo, Enrico Cherubini
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Brain Sciences
Subjects:
depolarizing GABA<sub>A</sub>-mediated neurotransmission
cation-chloride co-transporters
KCC2 dysfunction
Alzheimer’s disease
NGF
AD11 transgenic mice
Online Access:https://www.mdpi.com/2076-3425/12/6/783

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https://www.mdpi.com/2076-3425/12/6/783

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