Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice

Epigenetic aging of human hematopoietic cells is not accelerated upon transplantation into mice

Abstract Background Transplantation of human hematopoietic stem cells into immunodeficient mice provides a powerful in vivo model system to gain functional insights into hematopoietic differentiation. So far, it remains unclear if epigenetic changes of normal human hematopoiesis are recapitulated up...

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Bibliographic Details
Main Authors: Joana Frobel, Susann Rahmig, Julia Franzen, Claudia Waskow, Wolfgang Wagner
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Clinical Epigenetics
Subjects:
Aging
DNA methylation
Epigenetic
Hematopoiesis
Humanized mice
Transplantation
Online Access:http://link.springer.com/article/10.1186/s13148-018-0499-7

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http://link.springer.com/article/10.1186/s13148-018-0499-7

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