NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Despite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics.

Bibliographic Details
Main Authors: Rose Hodgson, Xijin Xu, Consuelo Anzilotti, Mukta Deobagkar-Lele, Tanya L. Crockford, Jessica D. Kepple, Eleanor Cawthorne, Aneesha Bhandari, Alberto Cebrian-Serrano, Martin J. Wilcock, Benjamin Davies, Richard J. Cornall, Katherine R. Bull
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04118-w

Internet

https://doi.org/10.1038/s42003-022-04118-w

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