NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance
Despite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04118-w |
| _version_ | 1797988460867354624 |
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| author | Rose Hodgson Xijin Xu Consuelo Anzilotti Mukta Deobagkar-Lele Tanya L. Crockford Jessica D. Kepple Eleanor Cawthorne Aneesha Bhandari Alberto Cebrian-Serrano Martin J. Wilcock Benjamin Davies Richard J. Cornall Katherine R. Bull |
| author_facet | Rose Hodgson Xijin Xu Consuelo Anzilotti Mukta Deobagkar-Lele Tanya L. Crockford Jessica D. Kepple Eleanor Cawthorne Aneesha Bhandari Alberto Cebrian-Serrano Martin J. Wilcock Benjamin Davies Richard J. Cornall Katherine R. Bull |
| author_sort | Rose Hodgson |
| collection | DOAJ |
| description | Despite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics. |
| first_indexed | 2024-04-11T08:04:24Z |
| format | Article |
| id | doaj.art-071960c232c647ea9fe3a78b10f61494 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T08:04:24Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-071960c232c647ea9fe3a78b10f614942022-12-22T04:35:37ZengNature PortfolioCommunications Biology2399-36422022-11-015111410.1038/s42003-022-04118-wNDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-toleranceRose Hodgson0Xijin Xu1Consuelo Anzilotti2Mukta Deobagkar-Lele3Tanya L. Crockford4Jessica D. Kepple5Eleanor Cawthorne6Aneesha Bhandari7Alberto Cebrian-Serrano8Martin J. Wilcock9Benjamin Davies10Richard J. Cornall11Katherine R. Bull12MRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordWellcome Centre for Human Genetics, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordMRC Human Immunology Unit, Nuffield Department of Medicine, University of OxfordDespite an upregulation in anergic B cells, N-myc downstream-regulated gene 1 (NDRG1) is not required for the tolerogenic downstream responses, reducing risk of immune modulation on targeting of NDRG1 for cancer therapeutics.https://doi.org/10.1038/s42003-022-04118-w |
| spellingShingle | Rose Hodgson Xijin Xu Consuelo Anzilotti Mukta Deobagkar-Lele Tanya L. Crockford Jessica D. Kepple Eleanor Cawthorne Aneesha Bhandari Alberto Cebrian-Serrano Martin J. Wilcock Benjamin Davies Richard J. Cornall Katherine R. Bull NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance Communications Biology |
| title | NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance |
| title_full | NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance |
| title_fullStr | NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance |
| title_full_unstemmed | NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance |
| title_short | NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance |
| title_sort | ndrg1 is induced by antigen receptor signaling but dispensable for b and t cell self tolerance |
| url | https://doi.org/10.1038/s42003-022-04118-w |
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