Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia

Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia

Patients with liver cirrhosis can develop hyperammonemia and hepatic encephalopathy (HE), accompanied by pronounced daytime sleepiness. Previous studies with healthy volunteers show that experimental increase in blood ammonium levels increases sleepiness and slows the waking electroencephalogram. As...

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Bibliographic Details
Main Authors: Selena Marini, Olena Santangeli, Pirjo Saarelainen, Benita Middleton, Namrata Chowdhury, Debra J. Skene, Rodolfo Costa, Tarja Porkka-Heiskanen, Sara Montagnese
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Physiology
Subjects:
hyperammonemia
hepatic encephalopathy
sleep homeostasis
adenosine
metabolomics/metabolic profiling
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00636/full

Internet

http://journal.frontiersin.org/article/10.3389/fphys.2017.00636/full

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