Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disorder, characterized by an increased number of M1-like macrophages in the joints. Polyphyllin I (PPI), one of the main components in the Rhizoma of Paris polyphyllin, displays a selective inhibitory effect on various tumor cells. Here...

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Bibliographic Details
Main Authors: Qiong Wang, Xin Zhou, Yongjian Zhao, Jun Xiao, Yao Lu, Qi Shi, Yongjun Wang, Hongyan Wang, Qianqian Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
polyphyllin I
collagen-induced arthritis
primary macrophages
NF-κB
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02091/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02091/full

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