Circulating Tumor DNA from Ascites as an alternative to tumor sampling for genomic profiling in ovarian cancer patients

Circulating Tumor DNA from Ascites as an alternative to tumor sampling for genomic profiling in ovarian cancer patients

Abstract Genomic testing is crucial for the management of ovarian cancer. DNA from biopsies at diagnostic laparoscopies or interval debulking surgery after neoadjuvant chemotherapy, has a high failure rate. At relapse, biopsies may not be feasible. The aim of our study was to evaluate the feasibilit...

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Bibliographic Details
Main Authors: Maria Kfoury, Reda El Hazzaz, Claire Sanson, Felix Blanc Durand, Judith Michels, Emeline Colomba Blameble, Roseline Tang, Audrey Le Formal, Elodie Lecerf, Sebastien Gouy, Amandine Maulard, Patricia Pautier, Etienne Rouleau, Alexandra Leary
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Biomarker Research
Subjects:
Circulating Tumor DNA
Ovarian cancer
Homologous recombination deficiency
Genomic instability score
Ascites
Online Access:https://doi.org/10.1186/s40364-023-00533-1

Internet

https://doi.org/10.1186/s40364-023-00533-1

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