Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

<p>Abstract</p> <p>Background</p> <p>The Nef protein of HIV facilitates virus replication and disease progression in infected patients. This role as pathogenesis factor depends on several genetically separable Nef functions that are mediated by interactions of highly co...

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Bibliographic Details
Main Authors: Meuwissen Pieter J, Stolp Bettina, Iannucci Veronica, Vermeire Jolien, Naessens Evelien, Saksela Kalle, Geyer Matthias, Vanham Guido, Arien Kevin K, Fackler Oliver T, Verhasselt Bruno
Format: Article
Language:English
Published: BMC 2012-04-01
Series:Retrovirology
Subjects:
HIV
Nef
Sequence motifs
SH3 domain binding
Cytoskeleton
Lck
Receptor downregulation
Infectivity
Replication
Online Access:http://www.retrovirology.com/content/9/1/34

Internet

http://www.retrovirology.com/content/9/1/34

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