In vivo characterization of a podocyte-expressed short podocin isoform

In vivo characterization of a podocyte-expressed short podocin isoform

Abstract The most common genetic causes of steroid-resistant nephrotic syndrome (SRNS) are mutations in the NPHS2 gene, which encodes the cholesterol-binding, lipid-raft associated protein podocin. Mass spectrometry and cDNA sequencing revealed the existence of a second shorter isoform in the human...

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Bibliographic Details
Main Authors: Linus Butt, David Unnersjö-Jess, Dervla Reilly, Robert Hahnfeldt, Markus M. Rinschen, Katarzyna Bozek, Bernhard Schermer, Thomas Benzing, Martin Höhne
Format: Article
Language:English
Published: BMC 2023-12-01
Series:BMC Nephrology
Subjects:
Podocin
Podocin isoform
Transgenic mouse
Slit-diaphragm morphology
Online Access:https://doi.org/10.1186/s12882-023-03420-x

Internet

https://doi.org/10.1186/s12882-023-03420-x

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