IL-10-producing Th1 cells possess a distinct molecular signature in malaria

IL-10-producing Th1 cells possess a distinct molecular signature in malaria

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Control of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response. However, these IL-10–producing Th1 (induced type I regulatory [Tr1]) cells can also promote...

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Bibliographic Details
Main Authors: Chelsea L. Edwards, Susanna S. Ng, Fabian de Labastida Rivera, Dillon Corvino, Jessica A. Engel, Marcela Montes de Oca, Luzia Bukali, Teija C.M. Frame, Patrick T. Bunn, Shashi Bhushan Chauhan, Siddharth Sankar Singh, Yulin Wang, Jinrui Na, Fiona H. Amante, Jessica R. Loughland, Megan S.F. Soon, Nicola Waddell, Pamela Mukhopadhay, Lambros T. Koufariotis, Rebecca L. Johnston, Jason S. Lee, Rachel Kuns, Ping Zhang, Michelle J. Boyle, Geoffrey R. Hill, James S. McCarthy, Rajiv Kumar, Christian R. Engwerda
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-01-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Infectious disease
Online Access:https://doi.org/10.1172/JCI153733

Internet

https://doi.org/10.1172/JCI153733

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