Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Does Cholinergic Stimulation Affect the P2X7 Receptor-Mediated Dye Uptake in Mast Cells and Macrophages?

Background: Extracellular ATP is a powerful trigger of neuroinflammation by activating immune cells via P2X7 receptors. Acetylcholine and nicotinic agonists inhibit ATP-triggered proinflammatory cytokines via the so-called “cholinergic anti-inflammatory pathway” (CAP). However, it remains unclear as...

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Bibliographic Details
Main Authors: Dilyara Nurkhametova, Andrei Siniavin, Maria Streltsova, Denis Kudryavtsev, Igor Kudryavtsev, Raisa Giniatullina, Victor Tsetlin, Tarja Malm, Rashid Giniatullin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular Neuroscience
Subjects:
acetylcholine
nicotin
neuroinflammation
neurodegeneration
P2X7
mast cell
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2020.548376/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2020.548376/full

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