Importance of pharmacogenetic markers in the methylenetetrahydrofolate reductase gene during methotrexate treatment in pediatric patients with acute lymphoblastic leukemia

Importance of pharmacogenetic markers in the methylenetetrahydrofolate reductase gene during methotrexate treatment in pediatric patients with acute lymphoblastic leukemia

Despite remarkable progress in survival of children with acute lymphoblastic leukemia (ALL) which has reached about 85%, early toxicity and relapse rate remain issues that need to to be resolved. Genetic variants are important factors influencing the metabolism of cytotoxic drugs in ALL tre...

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Bibliographic Details
Main Authors: Lazić Jelena, Kotur Nikola, Krstovski Nada, Dokmanović Lidija, Zukić Branka, Predojević-Samardžić Jelica, Životić Maja, Milošević Goran, Đorić Milica, Janić Dragana, Pavlović Sonja
Format: Article
Language:English
Published: University of Belgrade, University of Novi Sad 2017-01-01
Series:Archives of Biological Sciences
Subjects:
pharmacogenetic markers
pediatric lymphoblastic leukemia
MTHFR c.677
MTHFR c.1298
Online Access:http://www.doiserbia.nb.rs/img/doi/0354-4664/2017/0354-46641600091L.pdf

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http://www.doiserbia.nb.rs/img/doi/0354-4664/2017/0354-46641600091L.pdf

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