Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis

Dysregulated follicular regulatory T cells and antibody responses exacerbate experimental autoimmune encephalomyelitis

Abstract Background Follicular regulatory T (TFR) cells are essential for the regulation of germinal center (GC) response and humoral self-tolerance. Dysregulated follicular helper T (TFH) cell-GC-antibody (Ab) response secondary to dysfunctional TFR cells is the root of an array of autoimmune disor...

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Bibliographic Details
Main Authors: Lin Luo, Xianzhen Hu, Michael L. Dixon, Brandon J. Pope, Jonathan D. Leavenworth, Chander Raman, William R. Meador, Jianmei W. Leavenworth
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
CNS autoimmunity
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Humoral antibody response
Follicular regulatory T cells
Treg lineage stability
Online Access:https://doi.org/10.1186/s12974-021-02076-4

Internet

https://doi.org/10.1186/s12974-021-02076-4

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