HDAC Inhibitors Enhance Efficacy of the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T in Pancreatic and Triple-Negative Breast Cancer Models

HDAC Inhibitors Enhance Efficacy of the Oncolytic Adenoviruses Ad∆∆ and Ad-3∆-A20T in Pancreatic and Triple-Negative Breast Cancer Models

The prognosis for triple-negative breast cancer (TNBC) and pancreatic ductal adenocarcinoma (PDAC) is dismal. TNBC and PDAC are highly aggressive cancers with few treatment options and a potential for rapid resistance to standard-of-care chemotherapeutics. Oncolytic adenoviruses (OAds) represent a p...

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Bibliographic Details
Main Authors: María Del Carmen Rodríguez Rodríguez, Inés García Rodríguez, Callum Nattress, Ahad Qureshi, Gunnel Halldén
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
oncolytic adenovirus
epigenetic
histone deacetylase inhibitor
HDACi
TNBC
PDAC
Online Access:https://www.mdpi.com/1999-4915/14/5/1006

Internet

https://www.mdpi.com/1999-4915/14/5/1006

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