A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.

A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.

The activities of the phospholipase C gamma (PLCγ) 1 and 2 enzymes are essential for numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or PLCγ2 activity is associated with multiple maladies including immune disorders, cancers, and neurodegenerative diseases. Therefore, the modulati...

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Bibliographic Details
Main Authors: Ramya Visvanathan, Tadanobu Utsuki, Daniel E Beck, W Brent Clayton, Emma Lendy, Kuai-Lin Sun, Yinghui Liu, Kirk W Hering, Andrew Mesecar, Zhong-Yin Zhang, Karson S Putt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299541&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0299541&type=printable

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