Modulation of GLO1 Expression Affects Malignant Properties of Cells

Modulation of GLO1 Expression Affects Malignant Properties of Cells

The energy metabolism of most tumor cells relies on aerobic glycolysis (Warburg effect) characterized by an increased glycolytic flux that is accompanied by the increased formation of the cytotoxic metabolite methylglyoxal (MGO). Consequently, the rate of detoxification of this reactive glycolytic b...

Full description

Bibliographic Details
Main Authors: Antje Hutschenreuther, Marina Bigl, Nasr Y. A. Hemdan, Tewodros Debebe, Frank Gaunitz, Gerd Birkenmeier
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:International Journal of Molecular Sciences
Subjects:
glyoxalase 1
MCF-7 cells
HEK 293 cell
aerobic glycolysis
malignant transformation
methylglyoxal
Online Access:http://www.mdpi.com/1422-0067/17/12/2133

Internet

http://www.mdpi.com/1422-0067/17/12/2133

Similar Items