Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity has become an accepted characteristic of a population of cells, i...

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Bibliographic Details
Main Authors: Albert H Gough, Ning Chen, Tong Ying Shun, Timothy R Lezon, Robert C Boltz, Celeste E Reese, Jacob Wagner, Lawrence A Vernetti, Jennifer R Grandis, Adrian V Lee, Andrew M Stern, Mark E Schurdak, D Lansing Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4103836?pdf=render

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http://europepmc.org/articles/PMC4103836?pdf=render

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