Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

ABSTRACT Infection by retroviruses as HIV-1 requires the stable integration of their genome into the host cells. This process needs the formation of integrase (IN)-viral DNA complexes, called intasomes, and their interaction with the target DNA wrapped around nucleosomes within cell chromatin. To pr...

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Bibliographic Details
Main Authors: E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. F. Sousa, M. Métifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Munier-Lehmann, C. Richetta, M. Maisch, J. Dutrieux, J. Batisse, M. Ruff, O. Delelis, P. Lesbats, V. Parissi
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
retrovirus
host chromatine
HIV-1
integration
nucleosome
Online Access:https://journals.asm.org/doi/10.1128/mbio.01083-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01083-23

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