Mitochondrial complex III activity: from invasive muscle biopsies to patient-friendly buccal swab analysis

Abstract Drug-induced mitochondrial dysfunction is a common adverse effect, particularly in case of statins—the most prescribed drugs worldwide. These drugs have been shown to inhibit complex III (CIII) of the mitochondrial oxidative phosphorylation process, which is related to muscle pain. As muscl...

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Bibliographic Details
Main Authors: Tim Somers, Neeltje A. E. Allard, Sailay Siddiqi, Margit C. M. Janssen, Maria T. E. Hopman, Wim J. Morshuis, Frans G. M. Russel, Silvie Timmers, Tom J. J. Schirris
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-36741-w