Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion

Urocortin-2 Prevents Dysregulation of Ca2+ Homeostasis and Improves Early Cardiac Remodeling After Ischemia and Reperfusion

Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, we examined whether the addition of Ucn-2 in reperfusion promotes cardioprot...

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Bibliographic Details
Main Authors: Alejandro Domínguez-Rodríguez, Isabel Mayoral-Gonzalez, Javier Avila-Medina, Eva S. de Rojas-de Pedro, Eva Calderón-Sánchez, Ignacio Díaz, Abdelkrim Hmadcha, Antonio Castellano, Juan A. Rosado, Jean-Pierre Benitah, Ana M. Gomez, Antonio Ordoñez, Tarik Smani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
Urocortin-2
ischemia and reperfusion
adverse remodeling
Ca2+ dysregulation
store operated Ca2+ channels
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00813/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00813/full

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