Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats

A well-tolerated rAAV vector-mediated gene therapy in normotensive Brown Norway rats is used to reduce intraocular pressure in a dose dependent manner, encouraging further evaluations on pre-clinical models of glaucoma.

Bibliographic Details
Main Authors: Kristina J. Chern, Emily R. Nettesheim, Christopher A. Reid, Nathan W. Li, Gavin J. Marcoe, Daniel M. Lipinski
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-022-04134-w