Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats
A well-tolerated rAAV vector-mediated gene therapy in normotensive Brown Norway rats is used to reduce intraocular pressure in a dose dependent manner, encouraging further evaluations on pre-clinical models of glaucoma.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04134-w |
| _version_ | 1797984731380318208 |
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| author | Kristina J. Chern Emily R. Nettesheim Christopher A. Reid Nathan W. Li Gavin J. Marcoe Daniel M. Lipinski |
| author_facet | Kristina J. Chern Emily R. Nettesheim Christopher A. Reid Nathan W. Li Gavin J. Marcoe Daniel M. Lipinski |
| author_sort | Kristina J. Chern |
| collection | DOAJ |
| description | A well-tolerated rAAV vector-mediated gene therapy in normotensive Brown Norway rats is used to reduce intraocular pressure in a dose dependent manner, encouraging further evaluations on pre-clinical models of glaucoma. |
| first_indexed | 2024-04-11T07:06:19Z |
| format | Article |
| id | doaj.art-073bc42083044eb1a4e6aa037c1b6471 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T07:06:19Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-073bc42083044eb1a4e6aa037c1b64712022-12-22T04:38:22ZengNature PortfolioCommunications Biology2399-36422022-11-015111410.1038/s42003-022-04134-wProstaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway ratsKristina J. Chern0Emily R. Nettesheim1Christopher A. Reid2Nathan W. Li3Gavin J. Marcoe4Daniel M. Lipinski5Department of Cell Biology, Neurobiology and Anatomy, Medical College of WisconsinDepartment of Ophthalmology and Visual Sciences, Medical College of WisconsinDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of WisconsinDepartment of Ophthalmology and Visual Sciences, Medical College of WisconsinDepartment of Ophthalmology and Visual Sciences, Medical College of WisconsinDepartment of Cell Biology, Neurobiology and Anatomy, Medical College of WisconsinA well-tolerated rAAV vector-mediated gene therapy in normotensive Brown Norway rats is used to reduce intraocular pressure in a dose dependent manner, encouraging further evaluations on pre-clinical models of glaucoma.https://doi.org/10.1038/s42003-022-04134-w |
| spellingShingle | Kristina J. Chern Emily R. Nettesheim Christopher A. Reid Nathan W. Li Gavin J. Marcoe Daniel M. Lipinski Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats Communications Biology |
| title | Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats |
| title_full | Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats |
| title_fullStr | Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats |
| title_full_unstemmed | Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats |
| title_short | Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats |
| title_sort | prostaglandin based raav mediated glaucoma gene therapy in brown norway rats |
| url | https://doi.org/10.1038/s42003-022-04134-w |
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