Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus

Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus

Abstract Background During mitosis the cell depends on proper attachment and segregation of replicated chromosomes to generate two identical progeny. In cancers defined by overexpression or dysregulation of the MYC oncogene this process becomes impaired, leading to genomic instability and tumor evol...

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Bibliographic Details
Main Authors: Sarah A. Streeter, Alexandria G. Williams, James R. Evans, Jing Wang, Alissa D. Guarnaccia, Andrea C. Florian, Rafet Al-Tobasei, Qi Liu, William P. Tansey, April M. Weissmiller
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Genomics
Subjects:
N-MYC
WDR5
PDPK1
Mitosis
Chromosome segregation
Spindle pole
Online Access:https://doi.org/10.1186/s12864-024-10282-6

Internet

https://doi.org/10.1186/s12864-024-10282-6

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