Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

Tumour heterogeneity is thought to be a major barrier to successful cancer treatment due to the presence of drug resistant clonal lineages. However, identifying the characteristics of such lineages that underpin resistance to therapy has remained challenging. Here, we utilise clonal transcriptomics...

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Bibliographic Details
Main Authors: Sophia A Wild, Ian G Cannell, Ashley Nicholls, Katarzyna Kania, Dario Bressan, CRUK IMAXT Grand Challenge Team, Gregory J Hannon, Kirsty Sawicka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
tumor heterogeneity
cancer therapy
lineage tracing
single cell genomics
Online Access:https://elifesciences.org/articles/80981

Internet

https://elifesciences.org/articles/80981

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