Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model

Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model

We assessed the torsadogenic effects of a novel remyelinating drug clemastine for multiple sclerosis using an in vivo proarrhythmia model of acute atrioventricular block rabbit, since the drug has been demonstrated to suppress the human ether-á-go-go related gene (hERG) K+ channels. Bradycardia was...

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Detaylı Bibliyografya
Asıl Yazarlar: Satoshi Kawakami, Yoshinobu Nagasawa, Mihoko Hagiwara-Nagasawa, Kensuke Omura, Megumi Aimoto, Akira Takahara
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2020-11-01
Seri Bilgileri:Journal of Pharmacological Sciences
Konular:
Clemastine
Multiple sclerosis
QT-interval prolongation
Torsades de pointes
Online Erişim:http://www.sciencedirect.com/science/article/pii/S1347861320300839

Internet

http://www.sciencedirect.com/science/article/pii/S1347861320300839

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